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Osce #Mechanism of sulfonylureas- These exert the hypoglycaemic action by stimulating insulin secretion from the pancreatic beta-cell. Their primary mechanism of action is to close ATP-sensitive K-channels in the beta-cell plasma membrane, and so initiate a chain of events which results in insulin release. Insulin through GLUT-4 translocation cause peripheral uptake on glucose hence,decreasing hyperglycemia. About Age related cataract and diabetic cataract - Age related cataract -usually detected in more than half population after 65 years Diabetic cataract can occur even in younger age group as compared to age related cataract <65 yrs Age related cataract more common in females Diabetic cataract more common in males Age related cataract affects vision more as compared to diabetic cataract Diabetic cataract usually doesn't affect the vision but makes it difficult to examine fundus. Mechanism of diabetic cataract - the intracellular accumulation of sorbitol leads to osmotic cha